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Causes of SLE

Each clue is a genetic or environmental factor that has been implicated in causing or exacerbating SLE
Horizontales
HLA-DR2 and HLA-DR3, which make up the genes coding for _____, are predisposing alleles
__________ is implicated due to evidence that those with early menarche, those who use oral contraceptives, and those on hormonal therapy have increased risk of developing SLE. However, there is mixed evidence.
Use of __________ has a negative impact on almost every organ system involved in lupus: it predisposes to infections, increases risk of coronary artery disease, magnifies the impact of Raynaud’s, raises blood pressure, increases lupus skin disease, interferes with drugs used to treat lupus, compounds the risk for fragile bones, and affects digestion and liver metabolism.
One of several drugs that can cause SLE
The _________ pathway, especially type 1, is heavily implicated in the pathophysiology
See 1 Down
________, particularly with Epstein-Barr Virus, can increase risk
Genes associated with _____ immunity like TLR7 are implicated
Verticales
A role of ______ inactivation has been hypothesized, due to the fact that those with _______ Syndrome (see 2 Down) have much higher risk of SLE and those with _____ Syndrome (see 11 Across) have much lower risk
See 1 Down
Deficiencies in ___________ components, such as C1q, C4A, C4B, and C2
This heavy metal can be found in cleaning powders, soil, pottery materials, cement, and cigarette smoke, and occupational exposure can happen in mining, construction, and other industries.
Genes involved in ________ of immune complexes (DNASE1, TREX1) are implicated
Genes involved in lymphocyte _______ (PTPN22, BLK, BANK1, LYN) are implicated
There is mixed evidence on the role of _______, but patients with SLE are advised to wear SPF > 55 sunscreen to protect against it