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Wound Healing

Horizontales
Formation of a new blood vessels.
Healing and repair
Invasion of macrophage cells that are essential to healing by clearing debris, release growth factors, and promote collagen.
Cellular differentiation, scar formation, and scar remodeling.
Damage to blood vessels causing immediate vasoconstriction followed by vasodilation
Composed primarily of collagen, a substance which fills in the lesion, restoring tissue integrity and strength.
They secrete collagen and other connective tissue proteins.
Specialized cells responsible for wound contraction. They have features of both smooth muscle cells and fibroblasts.
Verticales
Complete healing and restoration of function with some destroyed tissues.
This grows into the wound from surrounding healthy connective tissue. It consists of invasion cells, new lymphatic vessels, and new capillaries.
Replacement of destroyed tissue with scar tissue.
Most abundant protein in the body. High concentrations of the amino acids glycine, proline, and lysine, many of which are enzymatically modified during the healing process.
Extensions from the plasma membrane of myofibroblasts establish connections between neighboring cells.