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Solvent and Vapor Toxicity

Horizontales
produces characteristic spectrum of developmental toxicity
property of solvents that decreases with increasing MW
dry cleaning fluid with carcinogenic effects
enzyme that mediates initial step in ethanol methanol and ethylene glycol metabolism to toxic products
major route of exposure to ethanol
major toxicity is hematopoietic, including anemia pancytopenia and leukemia
Verticales
chronic exposure or abuse produces classic leukoencephalopathy
benzene toluene and xylenes all fall into this chemical category
major toxic metabolite of chloroform
found in antifreeze, produces renal toxicity via oxalate crystal formation
most common route of solvent exposure
primary target tissue affected by exposure to methanol