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Chapter 9 Nucleic Acids as Drug Targets

Horizontales
Short DNA or RNA molecules, oligomers, that have a wide range of applications in genetic testing, research, and forensics
A nitrogen mustard derivative which binds to DNA, crosslinking both strands to prevent its replication
One of the most toxic anticancer drugs - acts as a prodrug, being converted into an alkylating agent within the body.
A type of anthracycline
Drugs which act by impairing the ability of the enzyme to religate cleaved DNA
a cancer medicine that interferes with the growth and spread of cancer cells in the body - doesn't cause bone marrow depression
an antiviral medication used for the treatment of herpes simplex virus infections
The process by which compounds containing planar aromatic or heteroaromatic ring systems are inserted between adjacent base pairs perpendicularly to the axis of the helix
an enzyme,that facilitates the joining of DNA strands
Also known as imidazole carboxamide, is a chemotherapy medication used in the treatment of melanoma and Hodgkin's lymphoma.
Verticales
A disinfectant bacteriostatic against many gram-positive bacteria, an example of an aminoacridine
Cytotoxic organic compounds with the chloroethylamine (Cl 2 NR 2) functional group. Although originally produced as chemical warfare agents, they were the first chemotherapeutic agents for treatment of cancer
a topoisomerase poison, isolated from the bark and stem of Camptotheca acuminata
DNA alkylating agents and are often used in -chemotherapy. They are lipophilic and can cross the blood-brain barrier
a class of antibiotics that act as chain cutters to kill bacteria
Anti-cancer agent which causes intra-strand cross-linking between quanine units
A naturally occurring antibiotic isolated from Streptomyces parvullus
a chemotherapy medication used for the treatments of a number of types of cancer - a podophyllotoxin
A form of therapy that uses antisense oligonucleotides (ASOs) to target messenger RNA (mRNA)