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Chapter 8 Receptors as Drug Targets

Horizontales
A class of corticosteroids, which are a class of steroid hormones
the maximum response achievable from an applied or dosed agent
Chemical substance which, upon binding to a receptor, leads to its activation
The primary female sex hormone
Study of the fate of substances administered to a living organism
Compounds that mimic the action of acetylcholine and/or butyrylcholine
Receptors that have inherent activity even in absence of agonist
Type of synthesis that results in a single enantiomer
A measure of drug activity expressed in terms of the amount required to produce an effect of given intensity
Compounds that can activate receptors but are unable to elicit the maximal response of the receptor system
Property of an object that is distinguishable from its mirror image
Receptors are a class of G protein–coupled receptors which bind histamine as their primary endogenous ligand
A type of estrogen
In radiolabeled experiments, the drug that competes with the radioligand
Verticales
A measure of the potency of a substance in inhibiting a specific biological or biochemical function
Type of receptor polypeptides that respond to the neurotransmitter acetylcholine
When a receptor decreases its response to an agonist at high concentration
Plot of the ratio [BL]/[L] versus [L]
A chemical substance that is released at the end of a nerve fiber by the arrival of a nerve impulse
The study of the biochemical and physiologic effects of drugs
The agonist concentration required to produce a specific level of effect when no antagonist is present
Method by which the receptor-drug complex is removed from the cell membrane
An enzyme inhibitor used to treat Alzheimer's
Approach to develop medications based on the knowledge of a biological target
A group of eye conditions that damage the optic nerve
Blocks the binding of an antagonists
Arenoceptors are a class of G protein-coupled receptors that are targets of many catecholamines
a steroid hormone, in the glucocorticoid class
A group of inhibitory G protein-coupled receptors with opioids as ligands