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Chapter 5 Medicinal Chemistry

Horizontales
Protein encoded by the SMO gene. Smoothened is a Class Frizzled (Class F) G protein-coupled receptor
An important secondary messanger
A type of tyrosine kinase that is encoded by the BTK gene in human
A multibranched polysaccharide of glucose
Belongs to the seronine-tyrosine kinase group
A class of the phosphatidylglycerides
Domain that binds PIP3
Receptor that binds Gi protein in CNS
Receptor that binds Gi protein in cardiac muscle
Forms cAMP from ATP
Peptide or small protein that induces a cell to begin mitosis
Treat manic depression disorders
Verticales
A protein which is a key regulator of Hedgehog (Hh) signaling in development and is mutated in human tumors
Released when the body requires immediate energy
Catalyzed by kinases
Interacts with muscarinic receptors
splits phosphatidylinositol into DAG and IP 3
Enzymes that were initially named "just another kinase"
Chain of events that takes place inside the cell after a ligand binds to a GPCR
Signal transduction pathway initiated by EGFR
A multifunctional intermediate calcium-binding messenger protein
Adapter protein that contains the SH2 domain
Ligands of the hedgehog signaling pathway
This domain can bind phosphatidylinositol lipids within biological membranes