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Psychopharmacology Chapter One

Horizontales
Molecule that binds to a receptor with some selectivity
Particular life-span; the number and sensitivity of receptors can change.
Drug may inhibit an enzyme, which also reduces metabolism of other drugs, effects are more intense/prolonged toxicity is possible.
Area postrema, cluster of cells in the brain stem that responds to toxins in the blood; induces vomiting.
Induces developmental abnormality, can include drugs, x-rays, and maternal infections such as German measles. Effects depend on exposure. Damage occurs the most during the first trimester.
Amount of drug in the blood that is free to bind at target sites.
Verticales
Brain capillaries are surrounded by glial feet -> extension of glial cell.
Also known as drug metabolism; occurs in the liver. Type 1 or phase 1; non-synthetic modification by oxidation, reduction and hydrolysis.
Study of the physiological and biological interaction of drug molecules with cell receptors in target tissues.
Repeated use of a drug increases number of enzymes molecules and speeds up biotransformation. Also can speed up transformation of other drugs that the enzyme acts on and reduces their effect.
Proteins on cell surfaces or within the cell.