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September TPN Puzzle

Horizontales
Articular symptoms are almost always polyarticular and _____
NSAIDS and corticosteroids should be used as a(n) ______ in relation to DMARD therapy.
What is the first-line therapy drug for the treatment of RA?
Patients will often feel stiffness in the _____(Think time of day)
Therapy is best optimized when started _______ to prevent irreversible damage (Think morning)
Etanercept is contraindicated if the patient has _______
What is one of the many contraindications in a patient who is being considered for methotrexate therapy? (Hint: Specific Drug discussed in COVID)
What is the dosing frequency of cholestyramine?
Folic acid supplementation has been shown to ______ MTX toxicity and adverse effects
Sulfasalazine should be taken with 8 ounces of _____ to prevent crystalluria
If a patient is started on rituximab, it is important that the team monitors ________ functioning (think running on the treadmill)
Which RA drug is the only one that is FDA approved to be given in combination with methotrexate?
What is one of the primary box warnings of methotrexate?
What is a contraindication of sulfasalazine?(Hint: Allergy)
Verticales
NSAIDS should not be used as _____ in RA treatment because they do not alter the course of the disease.
Infliximab is a(n) _______ antibody combining portions of mouse and human IgG1.
Essential component of non-pharmacological treatment ______(We don’t get enough of this)
Tocilizumab is considered a(n) _____ type of monoclonal antibody (what you and I are)
Xeljanz is dosed _____ times per day
Which medication, not commonly used, is known for reduced efficacy and toxicity in the treatment of RA?
Prescribe FA supplement for patients on sulfasalazine to prevent ______
If the patient is interested in becoming pregnant and is on Leflunomide therapy she might have to undergo a(n) _______ drug elimination procedure
Which RA drug is a naturally occurring IL-1 receptor antagonist? (brand name)
Methotrexate is a(n) ________ antagonist. (2 words)
Which non-TNF biologic also goes by the name CIMZIA™?
RA drug that urges caution in COPD patients is _____
Brand name of Leflunomide is _____