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CHEST Words Summer 2025

Horizontales
Number of needle passes during EBUS-TBNA recommended for malignant disease and suggested for nonmalignant per CHEST clinical practice guideline (MAR p. 900)
Replacing enzyme (augmentation) in severe alpha-1-antitrypsin deficiency does not protect this organ, so genomic medicines are being studied (FEB p446)
Dupilimab is a biologic to consider in a patient with severe asthma, elevated FENO, low eosinophils, and nasal ____ (FEB p.337)
___ levels are elevated in a majority of patients with sarcoidosis, it is produced in healthy lung and macrophages within granulomas. Patients treated with inhibitors of it, compared angiotensin receptor blockers, had increased mortality in one database study (MAR p.773)
Immunosuppression, especially steroids, can result in fatal hyperinfection. May not have eosinophilia. Ivermectin is treatment of choice (MAR p.689)
Flavored cigarettes were banned 15 years ago, except for ____. See Neptune et al, FEB p.324, for a review of its politicization
A research letter suggests subtracting 10 mm HG from displayed MAP to correct for semi-recumbant position when you put the blood pressure cuff on the ___ instead of the arm (FEB p.493)
This parasite may cause a salty taste in mouth (vomica) and hydatid cysts in organs, which, when ruptured, may show a floating membrane on CT resembling a water lily (MAR p.691)
Asthma review, asthma management plan, and checking ____ technique during one consultation reduced child asthma exacerbations by 30% in a large UK study (MAR p.665)
Bronchoscopic alveolar lavage (BAL) did not correlate with CT features in fibrotic ILD, including ground glass opacities not having a lot of this cell (JAN p.172)
___ modulators have transformed treatment of patients with CF, beginning with Ivacaftor in 2012 (FEB p.297)
Among donors for single lung transplant, less than ___ percent of the time is the second lung used (FEB p.312)
The PERFECT study, terminated early for safety concerns, studied inhaled Treprostinil in this most common cause of Group 3 pulmonary hypertension (JAN p.16)
Lymphangioleiomyomatosis (LAM) is a progressive, female-predominant, low grade neoplasm with high serum VEGF-D levels, and this benign renal tumor (FEB p.538)
Endemic mycosis infection that can range from asymptomatic pulmonary nodules to ARDS. Microscopically, they are a large, broad-based budding yeast (FEB p.381)
Pulse oximetry more frequently ___-estimates oxygen saturation in Black and Hispanic patients, impacting patient care (MAR p.832)
____ plugs on CT are found In up to 67% of people with COPD, though 30% do not have symptoms, and are associated with exacerbations and mortality (JAN p. 34)
Pneumocystis is a life-threatening opportunistic infection, increasingly in people without HIV. But it can also cause ___, or "the establishment in host organism without causing apparent disease", though may still affect prognosis (JAN p.55)
CHEST clinical practice guidelines value restrictive blood transfusion in adults, except those with acute ____ syndrome (FEB p.478)
We usually think of COPD in terms of FEV1, but better forced ____ flow rates may mean less severe exacerbations, slower decline, especially with specific inhaler devices (JAN p. 77)
___cessation in pulmonary langerhans histiocytosis (PLCH) can lead to disease stabilization and regression (FEB p.540)
40% of adults admitted with pneumonia get broad-spectrum coverage for MRSA or this gram negative organism, though these pathogens are recovered only 3% of the time (JAN p.25)
Verticales
A round parenchymal lucency, with a thin wall (2mm or less), surrounded by normal lung (FEB p.530)
The Global Lung Function Initiative (GLI) 2022 spirometry reference equations removed adjustment based on ___, for broader applicability, accuracy, and to reduce bias (FEB p.415)
A "___ to know me" board is a simple poster filled out by patient, family, or friends, in the ICU room to give clinical teams insight into a person's life before ICU admission (FEB p.315, 561)
First page of January edition lists 16 simulation courses available at CHEST headquarters, including one on use of ____, which pumps blood out of body to add O2 and remove CO2
1-855-5AMIVAS is a number to call for sodium artesunate to treat malaria, and this species is usually the most severe (MAR p.688)
A solid pulmonary nodule with surrounding ground glass opacity, known as the "___ sign", is suggestive of invasive aspergillosis (FEB p.380)
Most frequent complication in patients receiving endobronchial valves for lung volume reduction (FEB p.307)
Exercise testing shows more improvement with pulmonary ____ program than with bronchodilator therapy (JAN p.98)
In immunocompromised patients, detecting ___ suggests fungal growth (infection) and not colonization. As a dairy product stabilizer, aspiration could lead to false positive BAL results (FEB p.380)
____ is found in decaying wood and bird excreta, its polysaccharide capsule is its primary virulence factor, and infected immunocompromised patients should get a lumbar puncture regardless of symptoms (FEB p.379)
Activities that increase risk of fungal infections include gardening, construction, farming, cannabis inhalation, and this word for cave exploration (FEB p.381)
Treatment of choice for the primary driver of obstructive sleep apnea in children (MAR p.654)
Up to half of patients have dyspnea/exertional shortness of breath more than 3 months after acute pulmonary ___ (FEB p.586)
A 2015 multi-professional-society policy statement guides ICU teams when asked for potentially inappropriate treatment (MAR p.826). Lead author Gabe Bosslet chaired our 2024 CHEST meeting, which was in this city, the third largest in the Northeast
Idiopathic disease of granuloma formation, often self-limited, though emergency hospitalizations may have high mortality (JAN p.164)
Patients with ____ are at higher risk of extubation failure due to decreased thoracic compliance, reduced functional residual capacity, and more sleep apnea (JAN p.11)
CFTR modulators for cystic fibrosis may increase the chance of this, and they preserves lung function over those 9 months (FEB p.298,348)
The sophisticated gateway to the lungs, separating the passage of air from solids (JAN p.189)
In 1892, William Osler described this common condition as a monomorphic disease with intermittent symptoms (JAN p.1)
CHEST clinical practice guidelines for management of central airway obstruction suggests use of ____ bronchoscopy, as a conduit for ventilation, excellent suction, and passage of instruments (JAN p.288)