More research needs to be conducted to determine the genetic pharmacodynamic effects for this receptor.
________ have an alteration in their MC1R gene which produces alterations in drug metabolism
Linked to a sex chromosome and females more often affected than males
Study of DNA variation sequence as related to drug responses
Maternal inheritance only
Single stranded molecule with a structure of alternating sugar and phosphate group
Pharmacogenetic indications play and important role in drugs with:
Needs two carrier parents for offspring to develop disease
Primary enzyme of metabolism for anesthetic drugs
DNA variations result in sequences that are considered equally standard or normal in populations
Opioid used for pain control: a prodrug that may have decrease metabolism with altered CYP2B6*6 allele
Estimated to contribute to 20-50% of an individual's drug response
Verticales
A segment of DNA that codes for a specific protein
Series of three bases coding for one amino acid
Are important in drug disposition and tissue penetration. Mediate hepatobiliary, intestinal, and renal clearance
The entire set of genetic instructions
Lifestyle, age, disease severity, ethnicity
Huntington's disease is example of:
Uses genetic data to improve prediction of patient's responses to drugs
Step that converts DNA to RNA
Process by which the base sequence of an mRNA is used to organize and join amino acids into protein
Most common or prevalent sequence of DNA in a population
Genetic representation of his or her family tree
Phosphate group on DNA
Research suggested the use of this monitor should be used on red haired people to monitor depth of anesthestia
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