I can be used for many different reasons across different ICUs. I have a half-life of 10-20 minutes. I help with blood pressure but I have no inotropic or chronotropic effects.
I work in the distal renal tubules to increase Sodium Chloride and Water excretion while conserving Hydrogen and Potassium.
The one time you need to tell your patients to lay off the broccoli.
I mostly work on Alpha-1 receptors to cause smooth muscle contraction. I raise peripheral vascular resistance to increase blood pressure.
I am pivotal for the excitation and contraction of cardiac myocytes. I am also thought to enhance myocardial performance. (Hint: This is the most common medication form I'm given in)
I work as a smooth muscle relaxer therefore I vasodilate the peripheral vasculature. Careful at higher doses I can cause Cyanide toxicity.
I can cause thyroid and liver dysfunction. Careful when you bolus me, I am known to cause hypotension.
Class of medication that was originally used for Type 2 Diabetes but is now FDA approved for HF. It has been shown to decrease risk of CV death and hospitilzations for heart failure
You can give me many ways: IV, IM, and via an ETT. Watch out...when I'm given IV I can cause skin necrosis if I extravasate. Caution when using me with tachyarrhythmias, I can potentiate ectopy.
I have inotropic effects as well as lusitropy effects (aka I help with both systolic and diastolic function)
My peak effect time is 30-120 minutes. I'm given orally. Consider not giving me I'm having hypotension. Warn your male teenage patients prior to starting me....they might get a surprise.
Verticales
When giving me to neonates be sure to check my blood sugar.
I'm processed by the liver so you need less of me in patient's with liver dysfunction. Oddly I can cause swelling of the hands and feet.
If you use me at high doses for prolonged amounts of time I can lead to osteoporosis and adrenal gland insufficiency.
I am 40x more potent than my frequently used counterpart.
I have been linked to Reye's Syndrome when used in children with recent viral infections like the flu or chickenpox.
I'm a combo medication comprised of Valsartan and Sacubitril. I work well on patients with left ventricular systolic dysfunction.
When a patient is fluid overloaded, I'm an adjunct therapy that helps with the efficacy of other medicines like me. Rarely when I'm given alone it can be because the patient has kidney stones.
I can cause hearing loss especially when given at high doses or with antibiotics such as Gentamicin or Neomycin.
When I'm given as an infusion don't run me with Nicardipine because we do not like each other. I do play nice with things like Epinephrine and Milrinone.
I'm hormone who is excreted through urine. Notably I can cause pyloric-stenosis.
Decreases single-ventricle interstage mortality
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