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Alkylating Agents

Horizontales
PK studies can help optimize the dosing of this medication
Use of cryotherapy can prevent mucositis with this medication
PJP prophylaxis is recommended during the concomitant treatment phase of GBM with this medication
A major CNS toxicity of ifosfamide
This drug is a vesicant and cold compress and sodium thiosulfate can be used for extravasation
Newer alkylating agent indicated only in mSCLC
Prophylactic ____________ meds should be started 12h prior and until 24h after busulfan doses
______________ should be avoided with procarbazine due to risk for disulfiram-like reaction
Irreversible BMS with total doses of 6.5mg/kg may be seen with this drug
Boxed warning for pulmonary toxicity that can be seen mostly with doses > 1400mg/m2
Dacarbazine can cause hepatic _______ and therefore caution should be used in patients with hepatic dysfunction
Verticales
The active metabolite of ifosfamide and cyclophosphamide responsible for hemorrhagic cystitis
This drug can be used to reverse and treat CNS toxicity with ifosfamide
This medication has interactions with antiepiletics such as phenytoin and phenobarbital
This is a chemoprotective agent used to prevent hemorrhagic cystitis
This medication may be eliminated through the skin/sweat and patients should shower twice daily through 48h after receiving
The first alkylating agent used to treat lymphoma was _________ mustard
At least __ liters of hydration should be given per day with ifosfamide doses