región terminal de los cromosomas que los protegen frente a la degradación. Forman estructuras en forma de lazo y presentan diversas proteínas asociadas con funciones estructurales, de silenciamiento y control de la longitud de estos tras las replicación
Estructuras variables formadas por moléculas de mRNAs y proteínas y factores implicados en la traducción que van siendo apartadas durante el proceso de la misma. Tienen funciones relacionadas con la degradación, el almacenaje y el control de la traducción del mRNA
Un tipo de RNAs de interferencia formado por un dúplex de RNA de 19 a 25 nucleótidos con 2 sin complementar que adopta forma de horquilla. Son siempre endógenos y parcialmente complementarios al mRNA, sobre el que ejercen un efecto silenciador
proteínas que ayudan al plegamiento correcto de otras proteínas al unirse a grupos hidrofóbicos de su superficie que no deberían ser accesibles de estar bien plegadas.
segmentos de cadenas cortas de DNA sintetizados en la hebra "discontinua" durante el proceso de replicación en dirección 5'-3' a partir de cebadores de RNA que luego se eliminan. Se unen entre sí gracias a la acción de DNA ligasas.
Primer paso para la carga correcta del aminoácido al tRNA. Activación. Reacción entre el grupo carboxilo de un aminoácido y el fosfato interno del ATP en la que se forma un 5'-aminoacil adenilato y se libera un pirofosfato.
tRNAs que difieren en la secuencia del anticodón pero que unen el mismo aminoácido
conjunto de secuencias estructurales y reguladoras de DNA necesarias para codificar un producto génico, bien sea un RNA maduro o una proteína funcional
Fragmento correspondiente al extremo carboxiterminal obtenido al tratar la DNA polimerasa 1 de E.coli con tripsina. Tiene actividades polimerasa 5'-3' y exonucleasa 3'-5'.
Verticales
proteína en forma de anillo hexamérico cuya función es separar las dos hebras del DNA. Las DnaB bacterianas lo son.
Proceso de conjugación de proteínas para dirigirlas al proteasoma similar a la ubiquitinación, pero en procariotas.
Cys-proteasas que requieren calcio. Formadas por dos subunidades y están ampliamente expresadas en el cerebro y la médula espinal. Están implicadas en procesos de motilidad, adhesión celular y apoptosis en casos de desórdenes neurodegenerativos
proceso en el cual la información codificada en la secuencia de nucleótidos se convierte en una secuencia de aminoácidos
uno de los científicos que en 1961 demuestra la existencia del mRNA. Antes, ese mismo año, fue uno de los que propuso la hipótesis de la "molécula puente" entre el DNA y las proteínas
proteína involucrada en la terminación de la transcripción con forma de anillo que tiene dos dominios bien diferenciados, la región amino terminal le sirve para unirse al RNA y la carboxi terminal tiene actividad ATPasa
conjunto de secuencias del DNA que permiten el reconocimiento por parte de la RNA polimerasa y el inicio de la transcripción
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