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Study guide: RCT

Horizontales
assigns patients to group based on certain factors such as gender, age, comorbidites
if a research includes humans as the subjects then this must be approved before the study enrollment
all those involved in the study are NOT aware of the aspects of study
RCT are designed to look at the interventions from a current period of time onward
hypothesis: there is a difference between the intervention and control
type of double blinding that uses different dosing regimens but still maintains blinding
variables or factors that impact study if not accounted for
subjects are analyzed even if they withdrawal from the study
each participant receives both treatments: washout period is typically used
the ability to apply study results in the real world/ clinical practice
complete all aspects of the components of the study
Verticales
investigators OR subjects are aware of aspects of study
randomization that provides balanced number of subjects
characteristics or certain populations not to be included in the study
blinding is down to minimize this in a study
endpoint: main objective of the study, major effect caused by intervention
minimize cofounding; equal chance to be either intervention or control
endpoint: not the main outcomes but still important
those involved in the study are aware of all aspects
hypothesis: no difference between intervention or control