NFAT, NFkB, AP-1 are transcription factors that activate which gene
IL-4 is the cytokine that induces differentiation of this lymphocyte
Lymphocyte that activates barrier epithelium in GI, resp, UG tract and skin
Binding of TCR, CD8 and ___ activate naive CD8 T cells
Where t cells exit circulation and enter lymph nodes
B cell stage with IgM expressed on surface, B cell receptor is Ig expressed on surface
Loss of function mutations in ___ genes results in form of SCID which both T and B cells are absent
B cells with high affinity BCRs receive survival and activation signals in the ___
AID loss of function mutation results in _____ syndrome, and susceptibility to pyogenic bacteria such as pneumococcus and H influenzae
Deficiency in ___ results in no T cells but normal B cell levels (impairs B cell activation)
Where activated T cells exit lymph node
Antibody chain with VJ segments
Help B cells in germinal center response; found in lymphoid follicles
Area of germinal center where B cell proliferation takes place
Binding to of APC ___ to CD28 on T cell activates response
IFN-gama cytokine stimulate class switching to __
TFT-beta stimulates class switching to ___
Binds protein a of S aureus
Phenotype CD3+CD4_intracellular FoxP3+
Required for somatic hypermutation