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Adaptive Immune System

Horizontales
Stromal cells in bone marrow provide ___ as growth factor for B cell precursor development
Lymphocyte that activates helminths response
Deficiency in ___ causes low serum of all class-switched antibodies and increase susceptibility to infections to the resp and GI tracts
Lymphocyte that functions to activate macrophages
Cytokine responsible for T cell proliferation
Antibody chain with VDJ segment
Lymphocyte that amplifies neutrophil response to extracellular pathogens
Antibody used in parasitic infections
Kill cells harboring intracellular pathogens
B cell stage with RAG and IL-7A expression, D-J, V-DJ rearrangement
B cell stage with RAG expression, surrogate light chains, v-J rearrangment
TGF-beta and IL-10 are characteristic cytokines for this lymphocyte
Where DCs enter lymph nodes
IL-4 stimulates class switching to ___
Binding to of APC ___ to CD28 on T cell turns off response
Where mutation of hypervariable region of Ig genes takes place
Serine proteases --> apoptosis
B cell stage with IgM and IgD expressed on surface
These regions on ends of heavy and light chains combine to determine antigen specificity of the antibody
Aids in delivering contents of granules into the cytoplasm of target cell
Result of absence of RAG-1 or -2 expression
Verticales
NFAT, NFkB, AP-1 are transcription factors that activate which gene
IL-4 is the cytokine that induces differentiation of this lymphocyte
Lymphocyte that activates barrier epithelium in GI, resp, UG tract and skin
Binding of TCR, CD8 and ___ activate naive CD8 T cells
Where t cells exit circulation and enter lymph nodes
B cell stage with IgM expressed on surface, B cell receptor is Ig expressed on surface
Loss of function mutations in ___ genes results in form of SCID which both T and B cells are absent
B cells with high affinity BCRs receive survival and activation signals in the ___
AID loss of function mutation results in _____ syndrome, and susceptibility to pyogenic bacteria such as pneumococcus and H influenzae
Deficiency in ___ results in no T cells but normal B cell levels (impairs B cell activation)
Where activated T cells exit lymph node
Antibody chain with VJ segments
Help B cells in germinal center response; found in lymphoid follicles
Area of germinal center where B cell proliferation takes place
Binding to of APC ___ to CD28 on T cell activates response
IFN-gama cytokine stimulate class switching to __
TFT-beta stimulates class switching to ___
Binds protein a of S aureus
Phenotype CD3+CD4_intracellular FoxP3+
Required for somatic hypermutation