Reduces constipation by stimulating GI epithelial guanylyl cyclase
An oral antibiotic that is very poorly absorbed but kills bacteria (such as E. coli) contributing to IBS-D and traveler's diarrhea
A class of autonomic drugs that can produce an antispasmodic effect by inhibiting the branch of the ANS involved in "rest and digest"
An OTC type of oil that inhibits intestinal Ca channels, producing an antispasmodic effect in many patients
All biologics used to treat severe forms of IBD have a black box warning concerning an increased risk of this serious side effect
A serotonin 5-HT3 receptor antagonist approved only for women with treatment-resistant IBS-D, and which has a Black Box warning concerning potentially life threatening GI adverse effects.
The abbreviation applied to two different forms of bowel disease that are caused by dysregulation of GI mucosal immune function
Verticales
Several different "biologics" used in treating more severe forms of IBD act to reduce the effect of this important inflammatory cytokine
A class of drugs that can can reduce abdominal pain in many patients
A family of anti-inflammatory drugs used to treat moderate IBD that act primarily by reducing the expression of multiple types of genes involved in producing inflammatory responses
An anti-integrin monoclonal antibody used to treat severe or refractory IBD that produces its anti-inflammatory effects by preventing the movement of T cells across the GI endothelium into inflammed tissue
A type of bowel disease named after the physician who first characterized it
A family of compounds used to treat or control milder forms of IBD that produce anti-inflammatory effects by inhibiting COX & LOX
A potentially life threatening CNS disorder resulting from reactivation of a normally dormant virus that is enhanced by inhibiting vascular integrins involved in the normal trafficking of T cells from the bloodstream into brain tissue.
The abbreviation for a relatively common "idiopathic syndrome" that includes abdominal irritation & discomfort, and most commonly either diarrhea or constipation
Stimulation of intestinal secretion of this anion is an effective treatment for constipation
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