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The Complement System

Horizontales
Coats surface of pathogen to allow phagocytes to "grab" onto and ingest. Ex: C3b and C5b
Release of fluid from vessels due to increased vessel permeability
Antibody activated pathway of complement system
Type of phagocyte. Attracted by chemotaxis. Stick to inside of vessels to escape
Ingestion of large particles through formation of vesicles
Creates pores on pathogen membrane to puncture holes and kill cell Ex: C5-C9
The ultimate goal of MAC (Membrane attack complex)
White blood cell Three types: granulocytes, lymphocytes, monocytes
Verticales
Released by mast cells, cause vasodilation and increase vessel permeability
Pathway of complement system activated by membrane attack complex (MAC)
Make mast cells degranulate, Ex: C3a and C5a
Chemical signals sent to attract leukocytes to site of inflammation
Domino effect
Proteins that produce the cascade effect in complement system
Pathway of complement system NOT activated by antibodies
Cell that contains a "grab bag" of chemicals (granules) that when released produce a strong immediate inflammatory response