What happens to the plasma levels of a drug when its metabolism is induced
The species of an acid or base that is typically well absorbed, and who's concentration is affected by pH
A superfamily of enzymes that is responsible for the ~75% of all drug metabolism by the body
The term used to describe a drug-induced increase in expression of metabolizing enzyme(s)
A family of ATP dependent transporters that decreases the absorption of drugs taken orally by causing outward transport back into the intestinal lumen
In general, metabolism of drugs makes them more soluble in this fluid
This type of drug metabolism involves the formation of chemical bonds between drugs and large water soluble side groups (conjugation)
This type of drug does not readily cross the blood brain barrier
A protein found in high concentrations in blood that avidly binds many types of drugs
What happens to the plasma levels of a drug when its metabolism is inhibited
Verticales
A broad spectrum inducer of P-gp and P-450 isoforms
When taken orally, this drug chemical subtype is best absorbed across the lining of the stomach or neighboring duodenum
A drug taken for ulcers that also inhibits P-gp and P-450
Consuming the juice of this fruit can increase the bioavailability (and plasma concentration) of many drugs that are CYP3A4 substrates
Enzyme induction can cause this negative change in drug sensitivity
When taken orally, this drug chemical subtype is best absorbed in more alkaline regions of the small intestine
A type of drug that is inactive, and must first be metabolized to exert its biological effect
Foods and medications containing these elements will reduce the absorption of tetracyclines and some HIV medications due to chelation
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