A type of dose response curve most commonly used to describe drug effects in a large population of subjects
A type of agonist that produces the opposite effect of a full agonist.
The name applied to a receptor antagonist that binds irreversibly to the agonist binding site
The type of "index" used to define or measure drug safety. The larger this value, the safer the drug.
A European doctor named Paracelsus declared that at high doses, all drugs become this....
A term meaning rapid attenuation of agonist response
The branch of pharmacology that involves the study of "what drugs do to the body"
The biophysical term that reflects the maximal response produced by a drug at high concentrations
A type of receptor that undergoes dimerization and phosphorylation.
The acronym for the type of receptor that can exhibit constitutive activity
The term used to describe those receptors left when a maximal response is achieved when less than 100% of receptors are occupied by drug
The family of receptors responsible for mediating the effects of steroid and thyroid hormones
The name given to a drug that is not owned or registered (trademarked) to a drug company
Verticales
Ligands that interact with intracellular receptors share this biophysical property
A type of antagonist whose effect can be surmounted or overcome by elevating the concentration of the agonist
The parameter most commonly used to compare the potency of different agonists
The class of G proteins that inhibit adenylyl cyclase, and decrease cAMP levels
The branch of pharmacology that involves the study of "what the body does to drugs"
The term applied to an agonist that exerts effects similar to a competitive antagonist when administered in the presence of a 2nd drug that is a full agonist
A type of noncompetitive antagonist that binds to a different site than the agonist, and changes the shape of the agonist binding site
The abbreviation that reflects the concentration at which 50% of receptors are occupied by drug
The molecular target that almost all drugs interact with to exert their biological effects
Ligands that interact with receptors found on the cell surface usually have this biophysical property
The biophysical term that defines the strength of binding of a drug to its molecular target
The class of G proteins that stimulate adenylyl cyclase and increase cAMP levels
The name of an intracellular protein that binds to phosphorylated receptors, and enhances their internalization, and resulting desensitization of receptor mediated responses
A class of G proteins that cause the release of intracellular calcium. Also slang for "good looking guy".
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There is a 'Make Printable' button on the top left of your puzzle that will let you sign up for a plan or purchase a single puzzle.
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It looks weird when printed.
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99% of other printing issues have to do with printer settings. Instead of trying to fiddle with printer settings, which can be time-consuming and frustrating, there are a couple workarounds you can try.
You can try printing from a different browser, since different browsers have different default print settings. Alternately, you can try saving as a PDF (next to the print icon) and print that.
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We invested in building a number of premium features that free sites are unable to offer: the ability to automatically or manually add words to your puzzle, save-as-you-go puzzle editing, the ability to access your puzzles from any computer, an uncluttered and ad-free interface, the ability for friends and colleagues to solve your puzzles online, and quick responsiveness to reported issues.
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When you hit the 'Arrange' button, our algorithm will try to arrange all your words on the grid, and will move words around to try to fit the most words.
This will get all the words on the grid about 90% of the time, depending on the word list. For the other 10%, you will get an alert explaining that the words that did not fit were added to the scratchpad.
It prints on two pages.
Big puzzles won’t always print on one page — the clues and grid are the smallest we could make them while keeping them readable for everyone.
That said, different browsers print in slightly different ways, so you could try using 'print preview' using a different browser (or try the PDF button) to see if you like how that looks better.
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