A structural analog of another antimalarial drug. It also has some therapeutic efficacy for treating rheumatoid arthritis, but not COVID-19 (based on EBM).
An antimalarial also found in tonic water. At higher doses it can cause a constellation of side effects including tinnitus, headache, nausea, dizziness and visual disturbances. Contraindicated in anyone with a long QTc.
Verticales
One of two subtypes of Plasmodium that have a liver stage that can be challenging to eliminate by using most antimalarial drugs
One of the oldest antimalarial drugs. Overuse has resulted in widespread Plasmodium resistance. It produces its antiparasitic effect by getting concentrated in the acidic environment of parasite food vacuoles, where, due to its properties as a chemical base, makes the internal food vacuole pH less acidic. This causes the accumulation of toxic breakdown products of hemoglobin within the food vacuole, which normally become detoxified by a mechanism requiring an acidic pH. The build up of toxic Hb metabolites kills the parasite.
A group of natural products isolated from a Chinese shrub. They are WHO drugs of choice for treating choloroquine-resistant P. falciparum
Effective against P. vivax and P. ovale, and should never be given without first testing the patient for G6PD deficiency.
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There is a 'Make Printable' button on the top left of your puzzle that will let you sign up for a plan or purchase a single puzzle.
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It looks weird when printed.
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99% of other printing issues have to do with printer settings. Instead of trying to fiddle with printer settings, which can be time-consuming and frustrating, there are a couple workarounds you can try.
You can try printing from a different browser, since different browsers have different default print settings. Alternately, you can try saving as a PDF (next to the print icon) and print that.
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When you hit the 'Arrange' button, our algorithm will try to arrange all your words on the grid, and will move words around to try to fit the most words.
This will get all the words on the grid about 90% of the time, depending on the word list. For the other 10%, you will get an alert explaining that the words that did not fit were added to the scratchpad.
It prints on two pages.
Big puzzles won’t always print on one page — the clues and grid are the smallest we could make them while keeping them readable for everyone.
That said, different browsers print in slightly different ways, so you could try using 'print preview' using a different browser (or try the PDF button) to see if you like how that looks better.
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