A platinum analog that can cause SEVERE nausea & vomiting, as well as nephrotoxicity, myelosuppression and ototoxicity.
An inhibitor of topoisomerase II and causes myelosuppression
A Mab that binds to the PD-L1 ligand and prevents its activation of PD-1 receptors. This helps maintain immune responses against tumor cells
Binds to microtubules to cause mitotic arrest, and commonly causes peripheral neuropathy
Given to protect the bladder in patients taking an alkylating agent. Not to be confused with the organized for really smart people, which is spelled differently.
An antitumor peptide that produces dose-limiting pneumonitis, and more rarely, life-threatening pulmonary fibrosis
Forms a complex with leucovorin to inhibit thymidylate synthetase. (Note/Hint: numbers aren't supported in crossword puzzles)
An alkylating agent that must be bioactivated by P450 to be active, and can cause hemorrhagic cystitis
A type of cancer immunotherapy using a genetically modified T cell expressing chimeric antigen receptors to treat ALL.
Humanized Mab and checkpoint inhibitor that binds to the CTLA-4 receptor. This increases the activation & proliferation of anti-tumor T cells
This antitumor antibiotic produces free radicals that can cause CHF
This vinca alkaloid is known for causing peripheral neuropathy & associated constipation
Verticales
The name of a new type of cancer immunotherapay using a bi-specific T cell engager to treat B-cell precursor ALL
One of the first antineoplastic designer drugs that targets the cause of CML. IMHO - it was given a memorable but horrible trade name.
Targets cancer cells expressing HER2/neu that is overexpressed in ~25-30% of breast cancers. Can cause cardiomyopathy
A SERM used in the treatment of patients who are at high risk for, or have been diagnosed with, ER positive breast cancer.
Used to treat kidney cancer, prevent organ rejection, and keep coronary stents from re-stenosis. An inhibitor of mTOR.
A Mab that binds to and prevents the activation of PD-1 receptors, which causes anti-tumor T cells to remain activated and killing tumor cells
A folic acid antagonist used to treat both arthritis and cancer, and causes myelosuppression
This drug can come to the rescue in patients receiving too much of a commonly used antineoplastic
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It looks weird when printed.
First make sure you’ve published your puzzle. See the 'How do I print?' section above for more information.
99% of other printing issues have to do with printer settings. Instead of trying to fiddle with printer settings, which can be time-consuming and frustrating, there are a couple workarounds you can try.
You can try printing from a different browser, since different browsers have different default print settings. Alternately, you can try saving as a PDF (next to the print icon) and print that.
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When you hit the 'Arrange' button, our algorithm will try to arrange all your words on the grid, and will move words around to try to fit the most words.
This will get all the words on the grid about 90% of the time, depending on the word list. For the other 10%, you will get an alert explaining that the words that did not fit were added to the scratchpad.
It prints on two pages.
Big puzzles won’t always print on one page — the clues and grid are the smallest we could make them while keeping them readable for everyone.
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