Severe hypersensitivity reactions and hepatomegaly can occur if this member of a commonly used anti-HIV drug class is given to patients expressing the HLA-B*5701 allele
A drug that binds to the gp41 viral envelope glycoprotein and inhibits fusion of the virus with cell membranes
An abbreviation for a treatment regimen for HIV
A type of toxicity produced by the most commonly used anti-HIV drug class
The abbreviation of a relatively new class of anti-HIV drugs that inhibit viral integrase. A common component of cART multi-drug therapy.
This drug class can cause severe skin rashes (e.g. Stevens-Johnson syndrome), and is susceptible to viral resistance that can result from a single mutation.
The abbreviation for an anti-HIV drug class that is typically given along with low dose ritonavir, and which can cause redistribution of body fat
A humanized monoclonal IgG that binds selectively to CD4 and blocks entry of HIV into cells. A "post-attachment entry inhibitor" indicated for patients with multi-drug resistant HIV, in combination with other ARVs.
Verticales
A class of ARVs used to treat HIV whose absorption is reduced by multivalent cations found in antacids
This INSTI is contraindicated in pregnancy due to risk of birth defects
The nonproprietary names of all iNSTIs end with these same 8 letters
Pharmacokinetic changes associated with pregnancy can reduce plasma levels of this INSTI to sub-therapeutic levels.
An anti-HIV drug that is given at low doses as a "PI booster" to help maintain high ARV plasma levels to prevent the development of viral resistance.
Prevents the initial attachment of virus with mammalian cells by binding to the CCR5 co-receptor. Indicated for treatment-experienced adults with CCR5-tropic virus.
Has no direct effect on HIV by itself, even at high doses, but inhibits CYP3A4
All current anti-HIV drug combinations contain two members from this ARV drug class. This is because mutations can result in resistance to specific members of this drug class, but not to multiple members at the same time.
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It looks weird when printed.
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When you hit the 'Arrange' button, our algorithm will try to arrange all your words on the grid, and will move words around to try to fit the most words.
This will get all the words on the grid about 90% of the time, depending on the word list. For the other 10%, you will get an alert explaining that the words that did not fit were added to the scratchpad.
It prints on two pages.
Big puzzles won’t always print on one page — the clues and grid are the smallest we could make them while keeping them readable for everyone.
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