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BLOOD CLOT

Horizontales
Whole blood normally clots in 4–8 min when placed in a glass tube. Under these conditions, contact of the blood with glass activates factor XII, thereby initiating coagulation via the intrinsic pathway. Clotting is prevented if a chelating agent____________ is added.
Platelet activation and coagulation do not normally occur within an intact blood vessel. Thrombosis is prevented by several regulatory mechanisms that require healthy vascular endothelium. This substance synthesized by endothelial cells inhibit platelet activation
It is a 340,000-Da protein, is a dimer, each half of which consists of three pairs of polypeptide chains (designated Aα, Bβ, and γ). Disul- fide bonds covalently link the chains and the two halves of the molecule. It converted by Thrombin to fibrin monomers by releasing fibrinopep- tide A (a 16–amino acid fragment) and fibrinopeptide B (a 14–amino acid fragment) from the amino termini of the Aα and Bβ chains, respectively.
Verticales
This drug inhibit free and clot-associated factor Xa, which results in reduced thrombin generation. In turn, platelet aggregation and fibrin formation are suppressed.
This acid drug is lysine analogues that compete for lysine binding sites on plasminogen and plasmin, thereby blocking their interaction with fibrin.