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Anticoagulation Therapy

Horizontales
Thrombolytic agent used in clot resolution, given IV and may cause has a risk for hemorrhage when used with anticoagulants and antiplatelets.
Block or inhibit any step of the coagulation process
DVT/ PE prevention in hip and knee surgery. and stroke prevention in those with nonvalvular AF.
Antiplatelet agent , antipyretic and non-opioid analgesic. Onset 5-30 minutes and duration of 3-6 hr.
PARTIAL_THROMBOPLASTIN_TIME - Therapeutic range 1.5-2.5x baseline, dose adjustements for heparin, low molecular-weight heparins, and rivaroxaban.
Volume expander providing colloidal oncotic pressure in the intravascular space causing water shift back into intravascular space.
Common adverse reaction in all anticoagulation therapies.
Prevention of DVT/VTE/PE, subcutaneous route ONLY in hip and abdominal surgery.
Prophylactic anticoagulant for DVT/PE given subcutaneously or IV, has increased bleeding when used with oral anticoagulants, salicylates, penicillins or cephalosporins. Decreased anticoagulation with nitroglycerin.
Verticales
Interfere with aggregation process
The timeframe in which the patient will remain on heparin while warafrin reaches therapeutic levels and is usually about 3-5 days.
Antidote for heparin overdose, onset is 30 sec-1 minute lasting 2 hr.
Treatment of anticoagulant induced prothrombin deficiency.
Time required for clotting to occur, therapeutic range 1.3-1.5
Antiplatelet agent used in those with NSTEMI or recent CVA/MI , onset of 24 hr and duration 5 days
Oral anticoagulant, onset of three days and duration 4-5 days.
Cautioned in patients that are renal impaired, treats DVT and PE
Therapeutic range 2-3.5, standardized measurement of prothrombin used for warfarin adjustments.